|
KMID : 0043319950180020069
|
|
Archives of Pharmacal Research
1995 Volume.18 No. 2 p.69 ~ p.74
|
|
|
Recemization of L-Lysine for Pharmaceutical Synthesis and its Chiral Separation by GC-MS Spectroscopy
|
|
Cheong Jae-Yeon
Choi Su-Hang
Nam Tae-Woo
Shin Jae-Young
Kim Su-Woong
Jung Won-Tae
|
|
|
Abstract
|
|
|
|
In order to improve physico-chemical properties and to enhance stability of drugs, amino acid salt has been widely adoptd in pharmaceutical synthesis. Acetylsalicylic acid lysinate is one of the widely used analgesics and it is a good example of t5his synthesis. In the case of bacetylsalicylic acid lysinate synthesis, racemization of natrually occurred lysine is esential because the racemic lysine salt of the drug shows better yield, crystallinity and dryness than that of the L-lysine salt. To esatablish a simple, practical and economical process for L-lysine racemization, L-lysine treatments with phosphoric acid and with acetic acid were compared and the optimum conditions for its process and derivatization were investigated by chiral separation methods using GC_MS spectroscopy.
|
|
|
KEYWORD
|
|
|
Enantiomer, Acetylsalicylic acid, Lysine, Racemization, GC-MS, Chriral, TFA, PFPA
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|